Pyrazine contains two nitrogen atoms in its aromatic ring. Pyrazine play an important role
as intermediates for perfumes, pharmaceuticals, agricultural chemicals and food spices. Especially, amides and sulfonamides of pyrazines have been used
on various topics as anti-tuberculosis, dyes and pigments,oral anti diabetics, nutrition supplement, insecticides and fungicides.
In general pyrazine is prepared by the catalytic reaction of diamines with dioles ina vapour phase, dehydrogenation of piperazine or dealkylation of methyl pyrazine.
Pyrazine and their derivatives form an important class of compounds present in
several natural flavors and complex organic molecules, it is also responsible for
flavor in foodstuffs, like cheese, tea coffee, cooked meats nice aroma etc.
S. Ahmad, A. Maleki, Chem. Pharm. Bull., 56(1), 79-81 (2008).