2014-05-15
A mixture of 4-chloro benzonitrile and morpholine was subjected to microwave irradiation in solvent free condition to give 4-morpholino benzonitrile. Partial hydrolysis of 4-morpholino benzonitrile in 6N sodium hydroxide and 30% H2O2 resulted in 4-morpholino benzamide. A series of N-((2-hydroxynaphthalen-1-yl) (substituted phenyl) methyl)-4-morpholino benzamide was obtained in one pot synthesis by stirring 4-morpholino benzamide with aromatic aldehyde and ??naphthol in presence of oxalic acid as catalyst in solvent free condition.