The concept of performing more than one transformation in a single vessel, or developing one-pot processes, can generate less waste, reduce work-up procedures, avoid separation of unstable intermediates, save time and energy, and increase the efciency of the desired conversion. Since its discovery the Mizoroki?Heck reaction, which involves palladium catalyzed coupling of aryl halide and styrene, remains the best method for preparation of stilbene derivatives. This method has been a subject of extensive research, while it has been used for the synthesis of a large number of natural and articial molecules. In most cases the reaction is done with suitable aryl halide and a styrene or similar ole?n in the presence of small quantity of Pd-catalyst and stoichiometric amount of a base. Usually the aryl halide or in some cases aryl tri?ate and aryl diazonium salt are easily obtained either from a commercial source or prepared by known methods. The other component is usually a styrene or a derivative of acrylic acid/acrylonitrile etc.