Synthesis and c-Met Kinase Inhibition


c-Met is a unique receptor tyrosine kinase(RTK) structurally distinct from other RTK families. It is the cell surface receptor for hepatocyte growth factor(HGF) and is normally expressed by epithelial cells of many organs(liver, pancreas, prostate, kidney, muscle, and bone narrow) during embryogenesis and in adulthood. 

J.Med.Chem.2011,54, 2127-2142